BRADYKININ INDUCES ACUTE KIDNEY INJURY AFTER HYPOTHERMIC CIRCULATORY ARREST THROUGH THE REPRESSION OF THE NRF2-XCT PATHWAY

Bradykinin induces acute kidney injury after hypothermic circulatory arrest through the repression of the Nrf2-xCT pathway

Summary: Postoperative acute kidney injury Multipack Bottoms (AKI) is a common complication in patients undergoing deep hypothermic circulatory arrest (HCA); however, its underlying pathogenesis is unclear.In this study, we established a rat cardiopulmonary bypass model and demonstrated that hypothermia during HCA, rather than circulatory arrest, w

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New alternative therapeutic strategies against Pseudomonas aeruginosa, an opportunistic multi-resistant pathogen with a myriad of virulence factors

Pseudomonas aeruginosa (PA) has emerged as a significant cause of Gram-negative infections, Medical Carts particularly in patients with impaired host defenses.It is one of the six ESKAPE pathogens that majorly cause severe nosocomial infections.In addition to biofilm formation, PA possesses various virulence factors.It can be life-threatening due t

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Pleural carcinoid diagnosed via video-assisted thoracoscopy biopsies in a patient with recurrent unilateral pleural effusion at St. Francis hospital Nsambya: a case report

Abstract Background Pulmonary carcinoids are rare neuroendocrine tumors accounting for less than 1% of all lung cancers.They are classified into two subcategories; typical and atypical carcinoids with the latter tending to Door Closing Cam grow faster.Historically, open thoracotomy was the standard approach for pulmonary resection.However, in the r

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